I do think we need to tighten up our thinking about DNA (see lecture title). Crick did not discover DNA. As I recall it was Miescher who first identified DNA. Crick postulated a structure for DNA. He & Watson did not invent plectonemic winding in DNA and did not invent the idea of the complementarity of strands.
Moreover there is now a substantial body of evidence that duplex DNA is anyway a paranemic structure and the evidence for this has been fully set down, starting in 1991, again in 1997 and again in 2003 (www.notahelix.com/delmonte/index_delmonte.htm). This work has been referred to by J C Wang in his recent book and was known to Crick in 1991 when he received a copy of the book "Towards a New Structural Molecular Biology." The work was also referred to in a letter from Nobel Laureate Aaron Klug to Crick in 1991 and recorded in the Crick archive in London maintained by the Wellcome Foundation.
With the Sydney Centre for the Foundations of Science, the University of Sydney is a major locus of research into the nature and history of science. This blog is a simple way for the Sydney research community to keep in touch with each other.
I do think we need to tighten up our thinking about DNA (see lecture title). Crick did not discover DNA. As I recall it was Miescher who first identified DNA. Crick postulated a structure for DNA. He & Watson did not invent plectonemic winding in DNA and did not invent the idea of the complementarity of strands.
ReplyDeleteMoreover there is now a substantial body of evidence that duplex DNA is anyway a paranemic structure and the evidence for this has been fully set down, starting in 1991, again in 1997 and again in 2003 (www.notahelix.com/delmonte/index_delmonte.htm). This work has been referred to by J C Wang in his recent book and was known to Crick in 1991 when he received a copy of the book "Towards a New Structural Molecular Biology." The work was also referred to in a letter from Nobel Laureate Aaron Klug to Crick in 1991 and recorded in the Crick archive in London maintained by the Wellcome Foundation.